"mRNA (tissue)" shows the transcript level as nTPM, TS-score (Tissue Specificity score) corresponds to the score calculated as the fold change to the second-highest tissue. The 12 genes with the highest level of enriched expression in the brain and the tissue distribution category for the gene. Number of genes in the subdivided categories of elevated expression in the brain (based on transcript abundance) and the tissue distribution (based on expression above cut off) in the brain. Tissue enhanced: At least four-fold higher mRNA level in brain compared to the average level in all other tissues ( 1555).Group enriched: At least four-fold higher average mRNA level in a group of 2-5 tissues compared to any other tissue ( 637).Tissue enriched: At least four-fold higher mRNA level in brain compared to any other tissues ( 517).
Detected in many: Detected in at least a third but not all tissues including brain ( 5435)Įlevated expression in brain compared to other tissue types is divided into three different categories.Detected in some: Detected in brain and at least one more tissue, but less than one-third of tissues ( 2029).Detected in single: Detected only in brain ( 204).(B) The distribution of all genes across the six categories, based on transcript detection (nTPM≥1) in brain as well as in all other tissues.īrain expression is determined by expression above cut off (nTPM≥1). (A) The distribution of all genes across the five categories based on transcript abundance in brain as well as in all other tissues.
Regional specific summary pages including lists of regional elavated genes can be found here: cerebral cortex, olfactory bulb, hippocampal formation, amygdala, basal ganglia, thalamus, hypothalamus, midbrain, cerebellum, pons, medulla oblongata, spinal cord as well as white matter.įigure 2. Out of the genes with regional expression classification, 822 are categorized as genes with a regionally eleveted expression. Regional classification was based on 16507 genes are detected in the brain and included in all used external datasets. The transcriptome analysis shows that 82% (n= 16507) of all human proteins (n= 20090) are expressed in the brain (based on 13 brain regions, spinal cord and corpus callosum). For the regional classification the brain is divided into 13 anatomically defined regions, color coded in Figure 1.
Technical advances such as novel brain imaging methods analyses for detecting or localizing neural activity synergistic uses of multiple imaging modalities strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. Article formats include original research clinical case reports technological developments theoretical articles and synthetic reviews. Brain mapping research in both normal and clinical populations is encouraged. Imaging modalities of interest include positron emission tomography event-related potentials electro-and magnetoencephalography magnetic resonance imaging and single-photon emission tomography. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Human Brain Mapping publishes peer-reviewed basic clinical technical and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. Published by Wiley-Blackwell ISSN 1065-9471 HUM BRAIN MAPP Publication support | Impact factors